Abstract
The hallmark of rheumatoid arthritis (RA) is specific destruction of the synovial joints. In a mouse line that spontaneously develops a disorder with many of the features of human RA, disease is initiated by T cell recognition of a ubiquitously expressed self-antigen; once initiated, pathology is driven almost entirely by immunoglobulins. In this study, the target of both the initiating T cells and pathogenic immunoglobulins was identified as glucose-6-phosphate isomerase, a glycolytic enzyme. Thus, some forms of RA or related arthritides may develop by a mechanism fundamentally different from the currently popular paradigm of a joint-specific T cell response.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigen Presentation
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Antigen-Antibody Complex / immunology
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Antigen-Antibody Complex / metabolism
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Arthritis, Rheumatoid / immunology*
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Autoantibodies / immunology*
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Autoantigens / immunology*
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B-Lymphocytes / immunology*
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Cross Reactions
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Disease Models, Animal
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Glucose-6-Phosphate Isomerase / chemistry
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Glucose-6-Phosphate Isomerase / immunology*
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Humans
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Immunoglobulins / immunology
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Joints / immunology
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Mice
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Mice, Inbred C57BL
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Mice, Inbred NOD
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Mice, Transgenic
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Recombinant Fusion Proteins / immunology
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T-Lymphocytes / immunology*
Substances
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Antigen-Antibody Complex
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Autoantibodies
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Autoantigens
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Immunoglobulins
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Recombinant Fusion Proteins
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Glucose-6-Phosphate Isomerase