Molecular pathogenesis of Bacillus anthracis infection

Microbes Infect. 1999 Feb;1(2):131-9. doi: 10.1016/s1286-4579(99)80004-5.

Abstract

This review summarizes the current knowledge pertaining to the pathogenesis of infection with Bacillus anthracis relative to the two exotoxins and the capsule. Emphasis is given to the structure and activities of the individual components of the exotoxins, their interaction with cells, and the response of macrophages to lethal toxin. Finally, results from vaccination studies are reviewed.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthrax / immunology
  • Anthrax / microbiology*
  • Anthrax / prevention & control
  • Antigens, Bacterial / chemistry
  • Antigens, Bacterial / immunology
  • Bacillus anthracis / immunology
  • Bacillus anthracis / pathogenicity*
  • Bacterial Capsules / chemistry
  • Bacterial Capsules / immunology
  • Bacterial Toxins / chemistry*
  • Bacterial Toxins / immunology
  • Bacterial Vaccines / administration & dosage
  • Bacterial Vaccines / biosynthesis
  • Humans
  • Macrophages / immunology
  • Macrophages / microbiology*
  • Virulence

Substances

  • Antigens, Bacterial
  • Bacterial Toxins
  • Bacterial Vaccines
  • anthrax toxin