A human syndrome caused by immotile cilia

Science. 1976 Jul 23;193(4250):317-9. doi: 10.1126/science.1084576.

Abstract

Four subjects who produced immotile sperm were studied. In three of the subjects, who had frequent bronchitis and sinusitis, there was no mucociliary transport, as measured by tracheobronchial clearance. Electron microscopy indicated that cilia from cells of these patients lack dynein arms.

MeSH terms

  • Bronchitis / etiology
  • Bronchitis / pathology*
  • Chronic Disease
  • Cilia / pathology*
  • Cilia / ultrastructure
  • Humans
  • Kartagener Syndrome / embryology
  • Male
  • Models, Biological
  • Movement
  • Sinusitis / etiology
  • Sinusitis / pathology*
  • Situs Inversus / embryology
  • Sperm Motility
  • Sperm Tail / ultrastructure
  • Spermatozoa / pathology*
  • Syndrome