Abstract
An efficient new process is described for the synthesis of ecteinascidin ET-743 (1) and phthalascidin (2), starting from readily available cyanosafracin B (3).
MeSH terms
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Antineoplastic Agents, Alkylating / chemical synthesis*
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Antineoplastic Agents, Alkylating / chemistry
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Azocines*
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Dioxoles / chemical synthesis*
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Dioxoles / chemistry
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Indicators and Reagents
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Isoquinolines / chemical synthesis*
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Isoquinolines / chemistry
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Models, Molecular
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Molecular Conformation
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Phthalimides / chemical synthesis*
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Phthalimides / chemistry
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Quinones*
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Tetrahydroisoquinolines
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Trabectedin
Substances
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Antineoplastic Agents, Alkylating
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Azocines
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Dioxoles
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Indicators and Reagents
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Isoquinolines
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Phthalimides
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Quinones
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Tetrahydroisoquinolines
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cyanosafracin B
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phthalascidin
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Trabectedin