Abstract
Hypoxia-inducible factor 1alpha (HIF-1alpha) is a transcriptional factor that regulates genes involved in response to hypoxia and promotes neoangiogenesis, which are considered essential for tumor growth and progression. Using immunohistochemistry, we investigated the influence of HIF-1alpha expression on prognosis in 91 patients with cervical cancer stage pT1b. In univariate and multivariate analysis, patients with strong expression of HIF-1alpha had a significantly shorter overall survival time (P = 0.0307, log-rank test) and disease-free survival time (P < 0.0001, log-rank test) compared with those with moderate to absent HIF-1alpha expression. HIF-1alpha expression is a strong independent prognostic marker in early stage cervical cancer.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Biomarkers, Tumor / biosynthesis*
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Cell Nucleus / metabolism
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DNA-Binding Proteins / biosynthesis*
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Female
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Humans
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Immunohistochemistry
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Lymphatic Metastasis
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Multivariate Analysis
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Neoplasm Staging
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Nuclear Proteins / biosynthesis*
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Prognosis
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Survival Analysis
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Transcription Factors*
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Uterine Cervical Dysplasia / metabolism
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Uterine Cervical Dysplasia / pathology
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Uterine Cervical Neoplasms / metabolism*
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Uterine Cervical Neoplasms / pathology
Substances
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Biomarkers, Tumor
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DNA-Binding Proteins
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HIF1A protein, human
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Hypoxia-Inducible Factor 1
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Hypoxia-Inducible Factor 1, alpha Subunit
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Nuclear Proteins
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Transcription Factors