The efficacy and tolerability of a new weight-reduction agent, based on natural ingredients, was investigated in this randomized, placebo-controlled, double-blind study. The product reduces the absorption of different types of sugar from the gastrointestinal tract. Forty obese volunteers were included in the 12-week study. Body weight, body composition and blood pressure were recorded at baseline and every month during the study. The results show a significant difference in weight reduction in favour of the active group (3.5 kg versus 1.2 kg). Body composition measurements showed that > 85% of the reduction in the active group is fat loss. The tolerability was similar and good in both groups. This product shows promising results and should be studied more extensively at different dose levels.