Abstract
A diketopiperazine (1) has been isolated from the culture broth of Penicillium sp. F70614 and its structure has been determined to be cyclo(dehydroala-L-Leu) by various spectroscopic analyses. This compound selectively inhibited yeast alpha-glucosidase and porcine intestinal alpha-glucosidase with IC50 values of 35 and 50 microg/ml, respectively. However, it did not show significant inhibitory effects against almond beta3-glucosidase, Aspergillus alpha-galactosidase, Escherichia coli beta-galactosidase and jack bean alpha-mannosidase.
MeSH terms
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Binding, Competitive
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Fermentation
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Glycoside Hydrolase Inhibitors*
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Inhibitory Concentration 50
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Penicillium / chemistry*
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Penicillium / metabolism
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / pharmacology*
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Piperazines / chemistry
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Piperazines / isolation & purification
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Piperazines / pharmacology*
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alpha-Glucosidases / metabolism
Substances
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Cyclo(dehydroala-Leu)
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Enzyme Inhibitors
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Glycoside Hydrolase Inhibitors
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Peptides, Cyclic
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Piperazines
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alpha-Glucosidases