Abstract
Two patients with subacute sclerosing panencephalitis (SSPE) were treated safely and effectively with high doses of intravenous ribavirin combined with intraventricular alpha interferon. The ribavirin concentrations maintained in the serum and cerebrospinal fluid were higher than those which inhibit SSPE virus replication in vitro and in vivo.
MeSH terms
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Adolescent
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Antiviral Agents / administration & dosage
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Antiviral Agents / blood
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Antiviral Agents / cerebrospinal fluid
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Antiviral Agents / therapeutic use*
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Female
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Humans
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Infusions, Intravenous
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Male
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Ribavirin / administration & dosage
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Ribavirin / blood
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Ribavirin / cerebrospinal fluid
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Ribavirin / therapeutic use*
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Subacute Sclerosing Panencephalitis / blood
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Subacute Sclerosing Panencephalitis / cerebrospinal fluid
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Subacute Sclerosing Panencephalitis / drug therapy*
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Treatment Outcome
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Virus Replication / drug effects
Substances
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Antiviral Agents
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Ribavirin