New cyclic depsipeptide antibiotics, clavariopsins A and B, produced by an aquatic hyphomycetes, Clavariopsis aquatica. 1. Taxonomy, fermentation, isolation, and biological properties

J Antibiot (Tokyo). 2001 Jan;54(1):17-21. doi: 10.7164/antibiotics.54.17.

Abstract

Clavariopsins were isolated from the fermentation broth of Clavariopsis aquatica AJ 117363. Clavariopsins are cyclic depsipeptide antibiotics with the molecular weight of 1,153 and 1,139. Clavariopsins showed in vitro antifungal activity against not only Aspergillus fumigatus but also, although to a lesser extent, A. niger and Candida albicans.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology*
  • Aspergillus niger / drug effects
  • Candida albicans / drug effects
  • Depsipeptides*
  • Fermentation
  • Mice
  • Microbial Sensitivity Tests
  • Mitosporic Fungi / classification
  • Mitosporic Fungi / metabolism*
  • Molecular Structure
  • Peptides, Cyclic

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Depsipeptides
  • Peptides, Cyclic
  • clavariopsin A
  • clavariopsin B