Proteins of Mycobacterium bovis BCG induced in the Wayne dormancy model

C Boon; R Li; R Qi; T Dick

doi:10.1128/JB.183.8.2672-2676.2001

Proteins of Mycobacterium bovis BCG induced in the Wayne dormancy model

J Bacteriol. 2001 Apr;183(8):2672-6. doi: 10.1128/JB.183.8.2672-2676.2001.

Authors

C Boon¹, R Li, R Qi, T Dick

Affiliation

¹ Mycobacterium Laboratory, Institute of Molecular and Cell Biology, Singapore 117609, Republic of Singapore.

Abstract

Oxygen starvation triggers the shiftdown of the obligate aerobe Mycobacterium bovis BCG to a state of dormancy. Two-dimensional electrophoresis showed a drastic up-regulation of the alpha-crystallin homolog, the putative response regulator Rv3133c, and the two conserved hypothetical proteins Rv2623 and Rv2626c in dormant bacilli.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aerobiosis
Anaerobiosis
Bacterial Proteins / biosynthesis*
Crystallins / biosynthesis
Culture Media
Electrophoresis, Gel, Two-Dimensional
Models, Biological*
Mycobacterium bovis / genetics
Mycobacterium bovis / metabolism
Mycobacterium bovis / physiology*
Transcription, Genetic
Up-Regulation*

Substances

Bacterial Proteins
Crystallins
Culture Media