Abstract
The immune system provides protection from a wide range of pathogens. One component of immunity, the phylogenetically ancient innate immune response, fights infections from the moment of first contact and is the fundamental defensive weapon of multicellular organisms. The Toll family of receptors has a crucial role in immune defence. Studies in fruitflies and in mammals reveal that the defensive strategies of invertebrates and vertebrates are highly conserved at the molecular level, which raises the exciting prospects of an increased understanding of innate immunity.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis
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Biological Evolution*
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Drosophila / genetics
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Drosophila / immunology*
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Drosophila / microbiology
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Drosophila Proteins*
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Humans
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Immunity, Innate / genetics*
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Immunity, Innate / immunology*
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Infections / immunology
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Insect Proteins / genetics
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Insect Proteins / immunology*
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Interleukin-1 / chemistry
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Interleukin-1 / genetics
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Interleukin-1 / immunology
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / immunology*
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Phylogeny
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / immunology
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Signal Transduction
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Toll-Like Receptor 5
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Toll-Like Receptors
Substances
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Drosophila Proteins
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Insect Proteins
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Interleukin-1
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Membrane Glycoproteins
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Receptors, Cell Surface
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Tl protein, Drosophila
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Toll-Like Receptor 5
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Toll-Like Receptors
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tehao protein, Drosophila