Abstract
Bioassay-guided fractionation of organic extracts of Cladosporium herbarum, isolated from the marine sponge Callyspongia aerizusa, yielded two new macrolide metabolites: pandangolide 3 and 4 (1 and 2) and the known fungal metabolites pandangolide 2 (3), cladospolide B (4), and iso-cladospolide B (5). Also isolated were the antimicrobially active (against Bacillus subtilis and Staphylococcus aureus) furan carboxylic acids: Sumiki's acid (6) and its new derivative, acetyl Sumiki's acid (7). All structures were elucidated by spectroscopic methods.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Bacillus subtilis / drug effects
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Cladosporium / chemistry*
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Macrolides / chemistry
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Macrolides / isolation & purification*
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Macrolides / pharmacology
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Microbial Sensitivity Tests
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Molecular Structure
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Porifera / microbiology
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Macrolides
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pandangolide 3
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pandangolide 4