Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats

Phytother Res. 2001 May;15(3):213-8. doi: 10.1002/ptr.707.

Abstract

Tinospora cordifolia is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. Oral administration of 2.5 g and 5.0 g/kg body weight of the aqueous extract of the roots for 6 weeks resulted in a significant reduction in thiobarbituric acid reactive substances (TBARS) and an increase in reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in alloxan diabetic rats. The effect of Tinospora cordifolia root extract (TCREt) was most prominently seen in the case of rats given 5.0 g/kg body weight. The effect of TCREt was more effective than glibenclamide. Thus our study shows that TCREt exhibits antioxidant action in alloxan diabetes.

MeSH terms

  • Administration, Oral
  • Alloxan
  • Animals
  • Antioxidants / administration & dosage
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use
  • Blood Glucose / drug effects*
  • Catalase / drug effects
  • Diabetes Mellitus / chemically induced
  • Diabetes Mellitus / prevention & control*
  • Glutathione / drug effects
  • Magnoliopsida*
  • Male
  • Medicine, Ayurvedic
  • Phytotherapy
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Roots
  • Plants, Medicinal*
  • Rats
  • Rats, Wistar
  • Superoxide Dismutase / drug effects
  • Thiobarbituric Acid Reactive Substances / metabolism*

Substances

  • Antioxidants
  • Blood Glucose
  • Plant Extracts
  • Thiobarbituric Acid Reactive Substances
  • Alloxan
  • Catalase
  • Superoxide Dismutase
  • Glutathione