Abstract
Previous studies demonstrated that dietary exposure to 24 ppb 3,3',4,4',5-pentachlorobiphenyl (PCB 126) or 2.4 ppb 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced maxillary and mandibular proliferation of periodontal squamous epithelium, osteolysis of alveolar bone, and loose and displaced teeth in juvenile mink (Mustela vison). This study determined if such effects could be induced in laboratory rats. Feeding weanling male Long Evans rats 20 or 100 ppb PCB 126 or 1 or 10 ppb TCDD for up to 101 days caused a dose-dependent decrease in body weight gains but did not produce the jaw lesion observed in PCB 126- or TCDD-treated mink.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Body Weight / drug effects
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Cell Division / drug effects
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Diet
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Dose-Response Relationship, Drug
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Epithelium / drug effects
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Epithelium / pathology
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Jaw / drug effects*
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Jaw / pathology
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Male
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Osteolysis / chemically induced*
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Osteolysis / pathology
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Periodontal Ligament / drug effects*
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Periodontal Ligament / pathology
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Polychlorinated Biphenyls / administration & dosage
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Polychlorinated Biphenyls / toxicity*
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Polychlorinated Dibenzodioxins / administration & dosage
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Polychlorinated Dibenzodioxins / toxicity*
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Rats
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Rats, Long-Evans
Substances
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Polychlorinated Dibenzodioxins
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Polychlorinated Biphenyls
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3,4,5,3',4'-pentachlorobiphenyl