Abstract
TolC and its homologues are outer membrane proteins that are essential for the transport of many molecules across the cell envelope. In this study we characterized the gene encoding Vibrio cholerae TolC. V. cholerae tolC mutants failed to secrete the RTX cytotoxin, were hypersensitive to antimicrobial agents, and were deficient in intestinal colonization.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / metabolism*
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Bacterial Proteins / metabolism*
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Bacterial Toxins / metabolism*
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Bile / immunology*
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Bile Acids and Salts / pharmacology
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Drug Resistance, Microbial
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Escherichia coli Proteins
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Hemolysin Proteins
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Humans
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Membrane Transport Proteins
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Mice
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Mutagenesis, Insertional
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Tumor Cells, Cultured
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Vibrio cholerae / drug effects
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Vibrio cholerae / growth & development*
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Vibrio cholerae / immunology
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Vibrio cholerae / pathogenicity
Substances
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Anti-Bacterial Agents
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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Bacterial Toxins
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Bile Acids and Salts
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Escherichia coli Proteins
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Hemolysin Proteins
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Membrane Transport Proteins
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tolC protein, E coli
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ApxI toxin, Bacteria