Abstract
Clostridium perfringens mutant strain 121A/91 shows neither enzymatic (phospholipase C) nor hemolytic activity. Nevertheless, the cpa gene and the corresponding alpha-toxin variant are detectable. Vaccination with this genetically constructed alpha-toxin variant, rAT121/91, induces antibodies capable of significantly reducing activities induced by wild-type toxin. Thus, rAT121/91 could be a useful vaccine candidate.
MeSH terms
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Amino Acid Substitution
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Animals
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Antibodies, Bacterial / immunology
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Antibodies, Monoclonal / immunology
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Antigenic Variation / genetics
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Antigenic Variation / immunology*
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology*
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Antigens, Bacterial / isolation & purification
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Bacterial Toxins / genetics
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Bacterial Toxins / immunology*
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Bacterial Toxins / isolation & purification
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Bacterial Vaccines / genetics
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Bacterial Vaccines / immunology*
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Bacterial Vaccines / isolation & purification
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Calcium-Binding Proteins*
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Clostridium Infections / prevention & control
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Clostridium perfringens / enzymology
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Clostridium perfringens / genetics
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Clostridium perfringens / immunology*
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Female
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Mice
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Mice, Inbred BALB C
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Mutagenesis
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Type C Phospholipases / genetics
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Type C Phospholipases / immunology*
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Type C Phospholipases / isolation & purification
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Vaccines, Synthetic / genetics
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Vaccines, Synthetic / immunology*
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Vaccines, Synthetic / isolation & purification
Substances
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Antibodies, Bacterial
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Antibodies, Monoclonal
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Antigens, Bacterial
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Bacterial Toxins
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Bacterial Vaccines
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Calcium-Binding Proteins
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Vaccines, Synthetic
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Type C Phospholipases
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alpha toxin, Clostridium perfringens