Abstract
The E2F transcription factor family determines whether or not a cell will divide by controlling the expression of key cell-cycle regulators. The individual E2Fs can be divided into distinct subgroups that act in direct opposition to one another to promote either cellular proliferation or cell-cycle exit and terminal differentiation. What is the underlying molecular basis of this 'push-me-pull-you' regulation, and what are its biological consequences?
MeSH terms
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Animals
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Apoptosis
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Cell Cycle
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Cell Cycle Proteins / physiology
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Cell Differentiation
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Cell Division
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Chromatin / metabolism
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DNA-Binding Proteins*
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E2F Transcription Factors
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E2F6 Transcription Factor
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Gene Expression Regulation
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Humans
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Mice
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Models, Genetic
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Neoplasms / etiology
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Protein Structure, Tertiary
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Retinoblastoma Protein / metabolism
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Transcription Factors / genetics
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Transcription Factors / physiology*
Substances
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Cell Cycle Proteins
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Chromatin
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DNA-Binding Proteins
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E2F Transcription Factors
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E2F6 Transcription Factor
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E2F6 protein, human
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E2f6 protein, mouse
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Retinoblastoma Protein
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Transcription Factors