Alpha-glucosidase inhibitory constituents from Cuscuta reflexa

Chem Pharm Bull (Tokyo). 2002 Jan;50(1):112-4. doi: 10.1248/cpb.50.112.

Abstract

Two new compounds, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenamide (4), and 7'-(4'-hydroxy,3'-methoxyphenyl)-N-[(4-butylphenyl)ethyl]propenamide (5) have been isolated from Cuscuta reflexa along with five known compounds, 6,7-dimethoxy-2H-1-benzopyran-2-one (1), 3-(3,4-dihydroxyphenyl)-2-propen-1-ethanoate (2), 6,7,8-trimethoxy-2H-1-benzopyran-2-one (3), 3-(4-O-beta-D-glucopyranoside-3,5-dimethoxyphenyl)-2-propen-1-ol (6), 2-(3-hydroxy-4-methoxyphenyl)-3,5-dihydroxy-7-O-beta-D-glucopyranoside-4H-1-benzopyrane-4-one (7), reported for the first time from this species. Structures of these compounds were determined by spectral analysis. These compounds showed strong inhibitory activity against alpha-glucosidase.

MeSH terms

  • Amides / isolation & purification*
  • Chromatography, Gel
  • Convolvulaceae / chemistry*
  • Enzyme Inhibitors / isolation & purification*
  • Glycoside Hydrolase Inhibitors*
  • Plant Extracts / chemistry
  • Spectrophotometry, Ultraviolet

Substances

  • 7'-(3',4'-dihydroxyphenyl)-N-((4-methoxyphenyl)ethyl)propenamide
  • 7'-(4'-hydroxy,3'-methoxyphenyl)-N-((4-butylphenyl)ethyl)propenamide
  • Amides
  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors
  • Plant Extracts