Abstract
Activation of T lymphocytes is thought to require at least two signals, one delivered by the T-cell receptor complex after antigen recognition, and one provided on engagement of co-stimulatory receptors, such as CD28. Recent studies are providing clues as to the specific signalling roles of co-stimulatory receptors. Furthermore, superimposition of inhibitory signals, such as those delivered by cytotoxic T-lymphocyte antigen 4 (CTLA-4), leads to a complex network of positive and negative co-stimulatory signals, the integration of which modulates immune responses.
MeSH terms
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Abatacept
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Animals
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Antigens, CD / metabolism
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Antigens, Differentiation / metabolism*
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B7-1 Antigen / metabolism
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B7-2 Antigen
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CD28 Antigens / metabolism*
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CTLA-4 Antigen
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Humans
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Immune Tolerance
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Immunoconjugates*
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Lymphocyte Activation
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Membrane Glycoproteins / metabolism
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Mice
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Models, Immunological
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Receptors, Antigen, T-Cell / metabolism
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Signal Transduction
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T-Lymphocytes / immunology*
Substances
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Antigens, CD
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Antigens, Differentiation
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B7-1 Antigen
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B7-2 Antigen
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CD28 Antigens
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CD86 protein, human
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CTLA-4 Antigen
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CTLA4 protein, human
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Cd86 protein, mouse
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Ctla4 protein, mouse
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Immunoconjugates
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Membrane Glycoproteins
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Receptors, Antigen, T-Cell
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Abatacept