Abstract
Spinach leaves were found to contain two potent antitumor promoters as detected by the activity against tumor promoter-induced Epstein-Barr virus activation. The active components were identified as 1-O-alpha-linolenoyl-2-O-(7Z,10Z,13Z)-hexadecatrienoyl-3-O-beta-D-galactopyranosyl-sn-glycerol and 1,2-di-O-alpha-linolenoyl-3-O-beta-D-galactopyranosyl-sn-glycerol by spectroscopic data and some chemical and enzymatic reactions. Their contents significantly varied with the cultivar and with the culture conditions.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anticarcinogenic Agents / chemistry
-
Anticarcinogenic Agents / isolation & purification
-
Anticarcinogenic Agents / pharmacology*
-
Cell Line
-
Drug Screening Assays, Antitumor
-
Electrophoresis, Polyacrylamide Gel
-
Glucosides / chemistry
-
Glucosides / isolation & purification
-
Glucosides / pharmacology*
-
Glycerol / analogs & derivatives
-
Glycerol / chemistry
-
Glycerol / isolation & purification
-
Glycerol / pharmacology*
-
Glycolipids / chemistry
-
Glycolipids / isolation & purification
-
Glycolipids / pharmacology*
-
Humans
-
Magnetic Resonance Spectroscopy
-
Plant Leaves / chemistry
-
Species Specificity
-
Spectrometry, Mass, Fast Atom Bombardment
-
Spinacia oleracea / chemistry*
Substances
-
1,2-dilinolenoyl-3-galactopyranosylglycerol
-
1-O-linolenoyl-2-O-hexadeca-7,10,13-trienoyl-3-O-galactopyranosylglycerol
-
Anticarcinogenic Agents
-
Glucosides
-
Glycolipids
-
Glycerol