Abstract
As invading viruses do not harbor functional ribosomes in their virions, successful amplification of the viral genomes requires that viral mRNAs compete with cellular mRNAs for the host cell translation apparatus. Several RNA viruses have evolved remarkable strategies to recruit the host translation initiation factors required for the first steps in translation initiation by host cell mRNAs. This review describes the ways that three families of RNA viruses effectively usurp limiting translation initiation factors from the host.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Capsid / genetics
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Capsid Proteins*
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Carrier Proteins / genetics
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Eukaryotic Cells / metabolism
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Eukaryotic Cells / virology*
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Eukaryotic Initiation Factor-4E
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Humans
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Peptide Initiation Factors / genetics
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Picornaviridae / genetics
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Picornaviridae / pathogenicity
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Protein Biosynthesis / genetics*
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RNA Virus Infections / genetics*
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RNA Viruses / genetics*
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RNA Viruses / pathogenicity
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RNA, Viral / genetics*
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Rotavirus / genetics
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Rotavirus / pathogenicity
Substances
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Capsid Proteins
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Carrier Proteins
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Eukaryotic Initiation Factor-4E
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Peptide Initiation Factors
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RNA, Viral
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capsid protein, Cricket paralysis virus