Abstract
Nonoliguric renal insufficiency is a well-known nephrotoxic consequence of aminoglycosides, although reversible tubular damage in the absence of any change in the renal function has been occasionally found. Reported herein are 2 representative cases of a reversible tubular damage due to prolonged aminoglycoside administration: a patient with a Fanconi-like syndrome of proximal tubular dysfunction and a patient with a syndrome of hypokalemic metabolic alkalosis associated with hypomagnesemia.
Copyright 2003 S. Karger AG, Basel
MeSH terms
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Aged
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Alkalosis / chemically induced
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects*
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Drug Administration Schedule
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Female
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Gentamicins / administration & dosage
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Gentamicins / adverse effects*
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Humans
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Hypokalemia / chemically induced
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Hypokalemia / metabolism
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Kidney Diseases / chemically induced*
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Kidney Diseases / physiopathology
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Kidney Tubules, Proximal / physiopathology*
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Magnesium / blood
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Magnesium / metabolism
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Magnesium Deficiency / chemically induced
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Magnesium Deficiency / metabolism
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Male
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Potassium Chloride / therapeutic use
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Tobramycin / administration & dosage
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Tobramycin / adverse effects*
Substances
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Anti-Bacterial Agents
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Gentamicins
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Potassium Chloride
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Magnesium
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Tobramycin