Aminoglycoside-induced reversible tubular dysfunction

Pharmacology. 2003 Mar;67(3):118-20. doi: 10.1159/000067797.

Abstract

Nonoliguric renal insufficiency is a well-known nephrotoxic consequence of aminoglycosides, although reversible tubular damage in the absence of any change in the renal function has been occasionally found. Reported herein are 2 representative cases of a reversible tubular damage due to prolonged aminoglycoside administration: a patient with a Fanconi-like syndrome of proximal tubular dysfunction and a patient with a syndrome of hypokalemic metabolic alkalosis associated with hypomagnesemia.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Alkalosis / chemically induced
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects*
  • Drug Administration Schedule
  • Female
  • Gentamicins / administration & dosage
  • Gentamicins / adverse effects*
  • Humans
  • Hypokalemia / chemically induced
  • Hypokalemia / metabolism
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / physiopathology
  • Kidney Tubules, Proximal / physiopathology*
  • Magnesium / blood
  • Magnesium / metabolism
  • Magnesium Deficiency / chemically induced
  • Magnesium Deficiency / metabolism
  • Male
  • Potassium Chloride / therapeutic use
  • Tobramycin / administration & dosage
  • Tobramycin / adverse effects*

Substances

  • Anti-Bacterial Agents
  • Gentamicins
  • Potassium Chloride
  • Magnesium
  • Tobramycin