Fluorescent detection of chemical warfare agents: functional group specific ratiometric chemosensors

Shi-Wei Zhang; Timothy M Swager

doi:10.1021/ja029265z

Fluorescent detection of chemical warfare agents: functional group specific ratiometric chemosensors

J Am Chem Soc. 2003 Mar 26;125(12):3420-1. doi: 10.1021/ja029265z.

Authors

Shi-Wei Zhang¹, Timothy M Swager

Affiliation

¹ Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

PMID: 12643690
DOI: 10.1021/ja029265z

Abstract

Indicators providing highly sensitive and functional group specific fluorescent response to diisopropyl fluorophosphate (DFP, a nerve gas (G-agent) simulant) are reported. Nonemissive indicator 2 reacts with DFP to give a cyclized compound 2+A- that shows a high emission due to its highly planar and rigid structure. Very weak emission was observed by the addition of HCl. Another indicator based on pyridyl naphthalene exhibits a large shift in its emission spectrum after reaction with DFP, which provides for quantitative ratiometric detection.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Chemical Warfare Agents / analysis*
Fluorescent Dyes / chemistry*
Indicators and Reagents / chemistry*
Organophosphorus Compounds / analysis*
Pyridines / chemistry*
Spectrometry, Fluorescence / methods*

Substances

Chemical Warfare Agents
Fluorescent Dyes
Indicators and Reagents
Organophosphorus Compounds
Pyridines