(Z)-sarcodictyin A, a new highly cytotoxic diterpenoid from the soft coral Bellonella albiflora

Yoichi Nakao; Satoru Yoshida; Shigeki Matsunaga; Nobuhiro Fusetani

doi:10.1021/np0205452

(Z)-sarcodictyin A, a new highly cytotoxic diterpenoid from the soft coral Bellonella albiflora

J Nat Prod. 2003 Apr;66(4):524-7. doi: 10.1021/np0205452.

Authors

Yoichi Nakao¹, Satoru Yoshida, Shigeki Matsunaga, Nobuhiro Fusetani

Affiliation

¹ Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

PMID: 12713406
DOI: 10.1021/np0205452

Abstract

A new cytotoxic diterpene, (Z)-sarcodictyin A, was isolated from the Japanese soft coral Bellonella albiflora.(1) Its structure was elucidated on the basis of 1D and 2D NMR analysis and chemical degradation. (Z)-Sarcodictyin A showed strong cytotoxicity against HeLa human cervix cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Cnidaria / chemistry*
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Female
HeLa Cells / drug effects
Humans
Japan
Molecular Conformation
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Stereoisomerism
Tumor Cells, Cultured / drug effects
Uterine Cervical Neoplasms

Substances

Alkaloids
Antineoplastic Agents
Diterpenes
sarcodictyin A