Interleukin-4 and interleukin-13 signaling connections maps

Science. 2003 Jun 6;300(5625):1527-8. doi: 10.1126/science.1085458.

Abstract

Cytokines are inflammatory mediators important in responding to pathogens and other foreign challenges. Interleukin-4 (IL-4) and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. In addition to their physiological roles, these cytokines are also implicated in pathological conditions such as asthma and allergy. IL-4 can stimulate two receptors, type I and type II, whereas IL-13 signaling is mediated only by the type II receptor (see the STKE Connections Maps). These cytokines activate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which may contribute to allergic responses. In addition, stimulation of the phosphatidylinositol 3-kinase (PI3K) pathway through recruitment of members of the insulin receptor substrate family may contribute to survival and proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Motifs
  • Animals
  • Asthma / immunology
  • Asthma / metabolism
  • Humans
  • Hypersensitivity / immunology
  • Hypersensitivity / metabolism
  • Interleukin-13 / metabolism*
  • Interleukin-13 Receptor alpha1 Subunit
  • Interleukin-4 / metabolism*
  • Lymphocyte Activation
  • Phosphatidylinositol 3-Kinases / metabolism
  • Phosphoproteins / metabolism
  • Phosphorylation
  • Phosphotyrosine / metabolism
  • Protein Structure, Tertiary
  • Protein-Tyrosine Kinases / metabolism
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / metabolism
  • Receptors, Interleukin / chemistry
  • Receptors, Interleukin / metabolism
  • Receptors, Interleukin-13
  • Receptors, Interleukin-4 / chemistry
  • Receptors, Interleukin-4 / metabolism
  • STAT6 Transcription Factor
  • Signal Transduction*
  • T-Lymphocytes / immunology
  • Trans-Activators / metabolism
  • src Homology Domains

Substances

  • IL13RA1 protein, human
  • Interleukin-13
  • Interleukin-13 Receptor alpha1 Subunit
  • Phosphoproteins
  • Receptors, Antigen, T-Cell
  • Receptors, Interleukin
  • Receptors, Interleukin-13
  • Receptors, Interleukin-4
  • STAT6 Transcription Factor
  • STAT6 protein, human
  • Trans-Activators
  • Interleukin-4
  • Phosphotyrosine
  • Phosphatidylinositol 3-Kinases
  • Protein-Tyrosine Kinases