Abstract
Composite lymphomas have rarely been reported in Hodgkin's disease (HD), except in the lymphocyte predominance sub-type, and immunohistochemical investigations have been performed in only few cases. We describe the histological and immunophenotypical findings in a case of composite nodular sclerosing HD and high-grade, large cell non-Hodgkin's lymphoma (NHL). In our case HD and NHL cells displayed striking morphological and immunophenotypical divergence, suggesting a lack of correlation between the two neoplasms.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antigens, CD / analysis
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Antigens, CD20
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Antigens, Differentiation, B-Lymphocyte / analysis
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Antineoplastic Agents / administration & dosage
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HLA-DR Antigens / analysis
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Histocompatibility Antigens Class II / analysis
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Hodgkin Disease / pathology*
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Humans
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Lewis X Antigen
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Lymphoma, Large B-Cell, Diffuse / pathology*
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Lymphoma, Non-Hodgkin / pathology*
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Male
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Membrane Glycoproteins / analysis
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Mucin-1
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Neoplasms, Multiple Primary / pathology*
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Phenotype
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Sialyltransferases / analysis
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beta-D-Galactoside alpha 2-6-Sialyltransferase
Substances
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Antigens, CD
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Antigens, CD20
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Antigens, Differentiation, B-Lymphocyte
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Antineoplastic Agents
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HLA-DR Antigens
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Histocompatibility Antigens Class II
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Lewis X Antigen
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Membrane Glycoproteins
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Mucin-1
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invariant chain
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Sialyltransferases
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beta-D-Galactoside alpha 2-6-Sialyltransferase