Abstract
The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NFkappaB-immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain / drug effects*
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Brain / metabolism
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Brain / pathology*
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Caspase 3
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Caspases / metabolism
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Cerebral Cortex / drug effects
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Cerebral Cortex / pathology
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Corpus Striatum / drug effects
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Corpus Striatum / pathology
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Erythropoietin / metabolism
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Erythropoietin / therapeutic use*
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Hippocampus / drug effects
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Hippocampus / pathology
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Hypoxia-Ischemia, Brain / drug therapy*
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Hypoxia-Ischemia, Brain / metabolism
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Hypoxia-Ischemia, Brain / pathology
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Immunohistochemistry
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Mice
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Mice, Inbred Strains
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NF-kappa B / metabolism
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Neuroprotective Agents / therapeutic use
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Thalamus / drug effects
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Thalamus / pathology
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Time Factors
Substances
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NF-kappa B
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Neuroprotective Agents
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Erythropoietin
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Casp3 protein, mouse
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Caspase 3
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Caspases