Switchable catalysis: modular synthesis of functionalized Pyrimidinones via selective sulfide and halide cross-coupling chemistry

Carrie Kusturin; Lanny S Liebeskind; Hayat Rahman; Kirby Sample; Barbara Schweitzer; Jiri Srogl; William L Neumann

doi:10.1021/ol035649y

Switchable catalysis: modular synthesis of functionalized Pyrimidinones via selective sulfide and halide cross-coupling chemistry

Org Lett. 2003 Nov 13;5(23):4349-52. doi: 10.1021/ol035649y.

Authors

Carrie Kusturin¹, Lanny S Liebeskind, Hayat Rahman, Kirby Sample, Barbara Schweitzer, Jiri Srogl, William L Neumann

Affiliation

¹ Pfizer Global Research and Development, St. Louis Laboratories, 800 North Lindbergh, St. Louis, Missouri, USA.

PMID: 14601997
DOI: 10.1021/ol035649y

Abstract

[reaction: see text] A general demonstration of orthogonal selectivity of the Liebeskind-Srogl cross-coupling protocol compared to the Suzuki-Miyaura and Stille variants is reported.