Abstract
We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Brain / metabolism
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Exons / genetics
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Eye / metabolism
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Genes
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Genome
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Humans
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Kallikreins / biosynthesis*
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Kallikreins / chemistry
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Kallikreins / genetics*
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Mice
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Molecular Sequence Data
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Nerve Tissue / metabolism*
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Nerve Tissue Proteins / biosynthesis
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Nerve Tissue Proteins / chemistry
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Nerve Tissue Proteins / genetics
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Organ Specificity
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Phylogeny
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Protein Structure, Tertiary
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Sequence Alignment
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Sequence Homology, Amino Acid
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Species Specificity
Substances
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Nerve Tissue Proteins
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KLK8 protein, human
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Kallikreins
Associated data
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GENBANK/AY318865
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GENBANK/AY377391
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GENBANK/BK001605