Abstract
A stereoseletive synthesis of 2,7-anhydrosialic acid derivative 18 was achieved from d-glucono-delta-lactone. A highly syn-selective addition of Grignard reagent to theN-benzylimine 8 served as a key step.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Gluconates / chemistry
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Lactones / chemistry*
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Models, Chemical
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Molecular Conformation
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Molecular Structure
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N-Acetylneuraminic Acid / analogs & derivatives*
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N-Acetylneuraminic Acid / chemical synthesis*
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N-Acetylneuraminic Acid / chemistry
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Stereoisomerism
Substances
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Gluconates
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Lactones
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glucono-1,4-lactone
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N-Acetylneuraminic Acid