Abstract
New norsesterterpenoids (3 and 4), a sesterterpenoid (6), pyrroloterpenoids (7-10), and a stereoisomer of kurospongin (5) were isolated, along with known furanosesterterpenes (11-15), from two marine sponges of the genus Sarcotragus. The gross structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of NMR and CD spectroscopy. The compounds were evaluated for cytotoxicity against five human tumor cell lines and were found to exhibit marginal to moderate activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Central Nervous System Neoplasms
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Colonic Neoplasms
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Drug Screening Assays, Antitumor
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Female
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Humans
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Korea
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Lung Neoplasms
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Ovarian Neoplasms
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Porifera / chemistry*
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Skin Neoplasms
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Stereoisomerism
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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Terpenes