Abstract
In the CA1 area of rat hippocampal slices, a combined application of 5-CT, a potent 5-HT(1A) and 5-HT(7) receptor agonist, and WAY 100635, a selective 5-HT(1A) receptor antagonist, resulted in a reversible increase of the CA1 extracellular population spike amplitude. In whole-cell recording from identified pyramidal neurons, the effects of 5-CT applied in the presence of WAY 100635 involved a reduction of the slow afterhyperpolarization (sAHP) and the frequency adaptation of action potential firing, which could be blocked by a specific 5-HT(7) receptor antagonist SB 269970. The results indicate that the activation of 5-HT(7) receptors increases the excitability of hippocampal CA1 pyramidal cells.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / drug effects
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Animals
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Dose-Response Relationship, Drug
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Dose-Response Relationship, Radiation
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Drug Interactions
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Electric Stimulation
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology
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Hippocampus / cytology*
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Hippocampus / drug effects
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In Vitro Techniques
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Male
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Phenols / pharmacology
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Piperazines / pharmacology
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Pyramidal Cells / drug effects
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Pyramidal Cells / physiology*
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Pyridines / pharmacology
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Rats
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Rats, Wistar
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / physiology*
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Serotonin / metabolism*
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Serotonin Antagonists / pharmacology
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Sulfonamides / pharmacology
Substances
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Phenols
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Piperazines
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Pyridines
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Receptors, Serotonin
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SB 269970
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Serotonin Antagonists
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Sulfonamides
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serotonin 7 receptor
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Serotonin
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N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide