Abstract
Thymidine kinase-negative mutants of herpes simplex virus did not reactivate from latency in mouse trigeminal ganglia, even when their latent viral loads were comparable to those that permitted reactivation by wild-type virus. Thus, reduced establishment of latency does not suffice to account for the failure to reactivate.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Herpes Simplex / virology
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Male
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Mice
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Molecular Sequence Data
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Mutation
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Simplexvirus / enzymology
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Simplexvirus / genetics
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Simplexvirus / physiology*
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Thymidine Kinase / genetics
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Thymidine Kinase / metabolism*
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Trigeminal Ganglion / virology*
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Virus Activation*
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Virus Latency*
Associated data
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GENBANK/AY326452
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GENBANK/AY326453