Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment

J Virol. 2004 Jan;78(1):520-3. doi: 10.1128/jvi.78.1.520-523.2004.

Abstract

Thymidine kinase-negative mutants of herpes simplex virus did not reactivate from latency in mouse trigeminal ganglia, even when their latent viral loads were comparable to those that permitted reactivation by wild-type virus. Thus, reduced establishment of latency does not suffice to account for the failure to reactivate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Herpes Simplex / virology
  • Male
  • Mice
  • Molecular Sequence Data
  • Mutation
  • Simplexvirus / enzymology
  • Simplexvirus / genetics
  • Simplexvirus / physiology*
  • Thymidine Kinase / genetics
  • Thymidine Kinase / metabolism*
  • Trigeminal Ganglion / virology*
  • Virus Activation*
  • Virus Latency*

Substances

  • Thymidine Kinase

Associated data

  • GENBANK/AY326452
  • GENBANK/AY326453