Abstract
Because migraine has been associated with dopaminergic receptor hypersensitivity, the authors hypothesized that patients with Parkinson disease with current or prior migraine have better dopaminergic response and less motor disability than Parkinson disease patients without migraine. Twenty-eight patients with Parkinson disease were included and matched (10 patients with migraine and 18 patients without migraine). Patients with Parkinson disease and migraine showed greater motor improvement during the ON state than patients without migraine with the same medication exposure. These data support the hypothesis that migraine may be associated with dopaminergic hypersensitivity.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Aged
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Aged, 80 and over
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Antiparkinson Agents / adverse effects
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Antiparkinson Agents / therapeutic use
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Case-Control Studies
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Cross-Sectional Studies
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Dopamine / physiology*
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Dopamine Agonists / adverse effects
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Dopamine Agonists / therapeutic use*
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Dyskinesias / drug therapy*
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Dyskinesias / etiology
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Female
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Humans
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Levodopa / adverse effects
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Levodopa / therapeutic use
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Male
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Middle Aged
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Migraine Disorders / chemically induced
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Migraine Disorders / complications
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Migraine Disorders / drug therapy*
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Motor Activity / drug effects
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Parkinson Disease / complications
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Parkinson Disease / drug therapy*
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Severity of Illness Index
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Single-Blind Method
Substances
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Antiparkinson Agents
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Dopamine Agonists
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Levodopa
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Dopamine