Abstract
A new series of ether lipid esters of cidofovir (CDV) were evaluated against vaccinia and cowpox viruses. Activity was dependent on number of atoms in the alkyl or alkoxyalkyl chain, the linker moiety, and the presence of a double bond in the alkoxyalkyl chains linked to the phosphonate moiety of CDV.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alkylation
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology*
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Cidofovir
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Cowpox virus / drug effects
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Cyclization
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Cytosine / analogs & derivatives*
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Cytosine / chemical synthesis*
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Cytosine / pharmacology*
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Humans
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Organophosphonates*
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Organophosphorus Compounds / chemical synthesis*
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Organophosphorus Compounds / pharmacology*
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Orthopoxvirus / drug effects*
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Structure-Activity Relationship
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Vaccinia virus / drug effects
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Viral Plaque Assay
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Virus Replication / drug effects*
Substances
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Antiviral Agents
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Organophosphonates
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Organophosphorus Compounds
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Cytosine
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Cidofovir