Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells

Fitoterapia. 2004 Jun;75(3-4):261-6. doi: 10.1016/j.fitote.2003.12.021.

Abstract

Scopoletin (1-50 microg/ml) inhibited the release of PGE2, TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner. These results suggest that scopoletin might suppress the production of such pro-inflammatory cytokines and exert inhibitory activity on LPS-induced PGE2 production through the depression of COX-2 expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / pharmacology*
  • Anti-Inflammatory Agents / therapeutic use
  • Artemisia*
  • Cell Line / drug effects
  • Cyclooxygenase 2
  • Dinoprostone / metabolism
  • Dose-Response Relationship, Drug
  • Interleukin-1 / metabolism
  • Interleukin-6 / metabolism
  • Isoenzymes / metabolism
  • Lipopolysaccharides
  • Macrophages / drug effects*
  • Macrophages / metabolism*
  • Mice
  • Phytotherapy*
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Scopoletin / administration & dosage
  • Scopoletin / pharmacology*
  • Scopoletin / therapeutic use
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Anti-Inflammatory Agents
  • Interleukin-1
  • Interleukin-6
  • Isoenzymes
  • Lipopolysaccharides
  • Tumor Necrosis Factor-alpha
  • Cyclooxygenase 2
  • Prostaglandin-Endoperoxide Synthases
  • Dinoprostone
  • Scopoletin