We assessed the feasibility of using a waist-mounted, wireless triaxial accelerometer (TA) to monitor human movements in an unsupervised home setting to detect changes in functional status. A pilot study was carried out with six healthy subjects aged 80-86 years. The subjects wore a TA unit every day for two to three months. Each morning they carried out a short routine of directed movements that included standing, sitting, lying and walking. Important movement variables were measured. During the rest of the day, subjects were monitored for falls, and variables such as metabolic energy expenditure were measured. All subjects remained healthy; there was no overall change in functional status and there were only slight fluctuations in health status. No longitudinal changes were detected in any of the variables measured during the directed routine. There was a moderate correlation between weekly self-reported health status and energy expenditure: subjects reported a lower health status for weeks in which they expended less energy. The TA system was found to be practical for long-term, unsupervised home monitoring. All subjects found the system simple to use and the TA unit unobtrusive and comfortable to wear. High compliance rates were achieved: the TA units were worn on 88% of the days in the study, for an average of 11.2 hours per day.