Abstract
A new study shows that Ras2 regulates GPI-anchor synthesis in the ER. Reciprocally, the targeted enzyme GPI-GlcNAc transferase regulates Ras2 signal output. This novel intersection of Ras2 signaling and an ER-localized protein complex has interesting implications for Ras function.
MeSH terms
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Cell Membrane / enzymology
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Cell Membrane / genetics
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Endoplasmic Reticulum / enzymology*
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Endoplasmic Reticulum / genetics
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Fungal Proteins*
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Glycosylphosphatidylinositols / biosynthesis*
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Glycosylphosphatidylinositols / genetics
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Macromolecular Substances
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N-Acetylglucosaminyltransferases / genetics
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N-Acetylglucosaminyltransferases / metabolism
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Protein Transport / genetics
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Signal Transduction / genetics
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ras Proteins / genetics
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ras Proteins / metabolism*
Substances
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Fungal Proteins
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Glycosylphosphatidylinositols
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Macromolecular Substances
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N-Acetylglucosaminyltransferases
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UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase
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ras Proteins