GPI-anchor synthesis: Ras takes charge

Dev Cell. 2004 Jun;6(6):743-5. doi: 10.1016/j.devcel.2004.05.011.

Abstract

A new study shows that Ras2 regulates GPI-anchor synthesis in the ER. Reciprocally, the targeted enzyme GPI-GlcNAc transferase regulates Ras2 signal output. This novel intersection of Ras2 signaling and an ER-localized protein complex has interesting implications for Ras function.

Publication types

  • Review

MeSH terms

  • Cell Membrane / enzymology
  • Cell Membrane / genetics
  • Endoplasmic Reticulum / enzymology*
  • Endoplasmic Reticulum / genetics
  • Fungal Proteins*
  • Glycosylphosphatidylinositols / biosynthesis*
  • Glycosylphosphatidylinositols / genetics
  • Macromolecular Substances
  • N-Acetylglucosaminyltransferases / genetics
  • N-Acetylglucosaminyltransferases / metabolism
  • Protein Transport / genetics
  • Signal Transduction / genetics
  • ras Proteins / genetics
  • ras Proteins / metabolism*

Substances

  • Fungal Proteins
  • Glycosylphosphatidylinositols
  • Macromolecular Substances
  • N-Acetylglucosaminyltransferases
  • UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase
  • ras Proteins