Abstract
The human genome contains at least 17 genes that are members of the aldehyde dehydrogenase (ALDH) superfamily. These genes encode NAD(P)(+)-dependent enzymes that oxidize a wide range of aldehydes to their corresponding carboxylic acids. Aldehydes are highly reactive molecules that are intermediates or products involved in a broad spectrum of physiologic, biologic, and pharmacologic processes. Aldehydes are generated during retinoic acid biosynthesis and the metabolism of amino acids, lipids, carbohydrates, and drugs. Mutations in several ALDH genes are the molecular basis of inborn errors of metabolism and contribute to environmentally induced diseases.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Aldehyde Dehydrogenase / metabolism*
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Aldehydes / metabolism
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Amino Acids / metabolism
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Animals
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Antineoplastic Agents, Alkylating / metabolism
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Cyclophosphamide / metabolism
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Ethanol / metabolism
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Fatty Acids / metabolism
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Folic Acid / biosynthesis
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Humans
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Lipid Peroxidation / physiology
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Tretinoin / metabolism
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Xenobiotics / metabolism*
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gamma-Aminobutyric Acid / biosynthesis
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gamma-Aminobutyric Acid / metabolism
Substances
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Aldehydes
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Amino Acids
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Antineoplastic Agents, Alkylating
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Fatty Acids
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Xenobiotics
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Ethanol
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gamma-Aminobutyric Acid
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Tretinoin
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Cyclophosphamide
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Folic Acid
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Aldehyde Dehydrogenase