Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives

M Gordaliza; P A García; J M Miguel del Corral; M A Castro; M A Gómez-Zurita

doi:10.1016/j.toxicon.2004.05.008

Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives

Toxicon. 2004 Sep 15;44(4):441-59. doi: 10.1016/j.toxicon.2004.05.008.

Authors

M Gordaliza¹, P A García, J M Miguel del Corral, M A Castro, M A Gómez-Zurita

Affiliation

¹ Departamento de Química Farmacéutica, Facultad de Farmacia, Universidad de Salamanca, 37007 Salamanca, Spain. mliza@usal.es

PMID: 15302526
DOI: 10.1016/j.toxicon.2004.05.008

Abstract

Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity on several neoplastic cell lines. Chemical transformations performed on these compounds have yielded derivatives more potent and more selective that the parent compound. Most of the compounds maintained their cytotoxicity at the microM level. Distribution, biosynthesis, production, biotechnology, applications and synthesis have also been reviewed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cytotoxins / chemistry
Cytotoxins / pharmacology*
Etoposide / analogs & derivatives*
Etoposide / chemistry
Etoposide / pharmacology
Lignans / classification
Organophosphorus Compounds / chemistry
Organophosphorus Compounds / pharmacology
Plants, Toxic / chemistry*
Podophyllotoxin / chemistry*
Podophyllotoxin / metabolism*
Podophyllotoxin / pharmacology*
Teniposide / chemistry
Teniposide / pharmacology
Tumor Cells, Cultured / drug effects

Substances

Cytotoxins
Lignans
Organophosphorus Compounds
etoposide phosphate
Etoposide
Teniposide
Podophyllotoxin