A remarkably efficient coupling of acid chlorides with alkynes in water

Liang Chen; Chao-Jun Li

doi:10.1021/ol048789w

A remarkably efficient coupling of acid chlorides with alkynes in water

Org Lett. 2004 Sep 2;6(18):3151-3. doi: 10.1021/ol048789w.

Authors

Liang Chen¹, Chao-Jun Li

Affiliation

¹ Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.

PMID: 15330610
DOI: 10.1021/ol048789w

Abstract

[reaction: see text] A highly effective direct coupling of acid chloride with terminal alkynes catalyzed by PdCl(2)(PPh(3))(2)/CuI together with a catalytic amount of sodium lauryl sulfate as the surfactant and K(2)CO(3) as the base provided ynones in high yields in water.