Abstract
Oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions and showed a central analgesic effect. Moreover, it significantly increased the plasma superoxide dismutase (SOD) and catalase activities and the high density lipoprotein-cholesterol level. On the contrary, the malondialdehyde (MDA) (as a measure of lipid peroxidation) level was significantly decreased in F. vulgare fruit methanolic extract group compared to the control group (P<0.05). These results seems to support the use of F. vulgare fruit methanolic extract in relieving inflammation.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Administration, Oral
-
Analgesics / administration & dosage
-
Analgesics / pharmacology
-
Analgesics / therapeutic use
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
-
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
-
Antioxidants / administration & dosage
-
Antioxidants / pharmacology
-
Antioxidants / therapeutic use
-
Arachidonic Acid
-
Carrageenan
-
Catalase / blood
-
Cholesterol, HDL / blood
-
Edema / chemically induced
-
Edema / prevention & control*
-
Foeniculum*
-
Fruit
-
Hot Temperature
-
Lipid Peroxidation / drug effects
-
Male
-
Mice
-
Mice, Inbred BALB C
-
Mice, Inbred ICR
-
Pain / chemically induced
-
Pain / prevention & control*
-
Phytotherapy*
-
Plant Extracts / administration & dosage
-
Plant Extracts / pharmacology*
-
Plant Extracts / therapeutic use
-
Rats
-
Rats, Sprague-Dawley
-
Superoxide Dismutase / blood
Substances
-
Analgesics
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antioxidants
-
Cholesterol, HDL
-
Plant Extracts
-
Arachidonic Acid
-
Carrageenan
-
Catalase
-
Superoxide Dismutase