Effects of the sGC stimulator BAY 41-2272 are not mediated by phosphodiesterase 5 inhibition

Circulation. 2004 Sep 21;110(12):e320-1; author reply e320-1. doi: 10.1161/01.CIR.0000142209.28862.12.
No abstract available

Publication types

  • Letter
  • Comment

MeSH terms

  • 3',5'-Cyclic-GMP Phosphodiesterases
  • Adenine / analogs & derivatives*
  • Adenine / pharmacology
  • Animals
  • Aorta / drug effects
  • Aorta / enzymology
  • Blood Platelets / drug effects
  • Blood Platelets / enzymology
  • CHO Cells / drug effects
  • CHO Cells / enzymology
  • Cricetinae
  • Cricetulus
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • Female
  • Genitalia / drug effects
  • Genitalia / enzymology
  • Guanylate Cyclase
  • Humans
  • Male
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / enzymology
  • Phosphodiesterase Inhibitors / pharmacology*
  • Phosphoric Diester Hydrolases / metabolism*
  • Piperazines / pharmacology
  • Purines
  • Pyrazoles / administration & dosage
  • Pyrazoles / pharmacology*
  • Pyridines / administration & dosage
  • Pyridines / pharmacology*
  • Rabbits
  • Rats
  • Receptors, Cytoplasmic and Nuclear / agonists*
  • Sildenafil Citrate
  • Soluble Guanylyl Cyclase
  • Sulfones

Substances

  • 3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine
  • Phosphodiesterase Inhibitors
  • Piperazines
  • Purines
  • Pyrazoles
  • Pyridines
  • Receptors, Cytoplasmic and Nuclear
  • Sulfones
  • 9-(2-hydroxy-3-nonyl)adenine
  • Sildenafil Citrate
  • Phosphoric Diester Hydrolases
  • 3',5'-Cyclic-GMP Phosphodiesterases
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • PDE5A protein, human
  • Pde5a protein, rat
  • Guanylate Cyclase
  • Soluble Guanylyl Cyclase
  • Adenine