Animal models of inflammatory bowel disease

Abdo R Jurjus; Naim N Khoury; Jean-Marie Reimund

doi:10.1016/j.vascn.2003.12.002

Animal models of inflammatory bowel disease

J Pharmacol Toxicol Methods. 2004 Sep-Oct;50(2):81-92. doi: 10.1016/j.vascn.2003.12.002.

Authors

Abdo R Jurjus¹, Naim N Khoury, Jean-Marie Reimund

Affiliation

¹ Department of Human Morphology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. aj00@aub.edu.lb

PMID: 15385082
DOI: 10.1016/j.vascn.2003.12.002

Abstract

In inflammatory bowel disease (IBD), experimental models have proven to be important tools for detecting potential therapeutic agents and for investigating the mechanisms of pathogenesis. This review is intended to cover recent advances in basic IBD model applications. The use of more than 20 animal models has allowed the detection of numerous protective pharmacological agents, including a number of immunomodulatory agents that have entered the therapeutic armamentarium. The models have been classified into five main categories based on the methods of induction: gene knockout (KO), transgenic, chemical, adoptive transfer, and spontaneous (each with subcategories).

Publication types

Review

MeSH terms

Adoptive Transfer
Animals
Animals, Genetically Modified
Colitis / drug therapy
Colitis / etiology
Colitis / pathology
Disease Models, Animal*
Humans
Inflammatory Bowel Diseases* / drug therapy
Inflammatory Bowel Diseases* / etiology
Inflammatory Bowel Diseases* / pathology
Mice
Mice, Knockout
Rats