Unprecedented acceleration of zirconium(IV)-assisted peptide hydrolysis at neutral pH

Inorg Chem. 2004 Oct 4;43(20):6130-2. doi: 10.1021/ic049433j.

Abstract

4,13-Diaza-18-crown-6 substantially increases the rate of zirconium(IV) hydrolysis of unactivated peptide amide bonds under near-physiological conditions of temperature and pH. In the presence of this azacrown ether, ZrCl(4) efficiently hydrolyses both neutral and negatively charged peptides (pH 7.0-7.3, 37-60 degrees C).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amides / chemistry
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Molecular Structure
  • Peptides / chemistry*
  • Time Factors
  • Zirconium / chemistry*

Substances

  • Amides
  • Peptides
  • Zirconium