Abstract
Genetic analysis of the embB gene revealed mutations in 17 (68%) of 25 ethambutol (EMB) resistant isolates (M306I, M306V, M306L, Q497R) but also in 4 (20%) of 20 EMB-susceptible isolates of Mycobacterium tuberculosis, namely, an ATG-->ATM substitution resulting in M306I, G406N, and the novel alterations M423I and A659T.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / pharmacology*
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Codon / genetics
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DNA Fingerprinting
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DNA Primers
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DNA, Bacterial / genetics
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Ethambutol / pharmacology*
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Genes, Bacterial / genetics
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Microbial Sensitivity Tests
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Mutation / genetics
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / genetics*
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Polymorphism, Genetic / genetics
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Reverse Transcriptase Polymerase Chain Reaction
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Singapore / epidemiology
Substances
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Antitubercular Agents
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Codon
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DNA Primers
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DNA, Bacterial
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Ethambutol