Generalized Langevin equation with fractional Gaussian noise: subdiffusion within a single protein molecule

Phys Rev Lett. 2004 Oct 29;93(18):180603. doi: 10.1103/PhysRevLett.93.180603. Epub 2004 Oct 29.

Abstract

By introducing fractional Gaussian noise into the generalized Langevin equation, the subdiffusion of a particle can be described as a stationary Gaussian process with analytical tractability. This model is capable of explaining the equilibrium fluctuation of the distance between an electron transfer donor and acceptor pair within a protein that spans a broad range of time scales, and is in excellent agreement with a single-molecule experiment.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • FMN Reductase / chemistry*
  • FMN Reductase / metabolism
  • Flavin-Adenine Dinucleotide / chemistry
  • Flavin-Adenine Dinucleotide / metabolism
  • Fluorescence
  • Models, Chemical*
  • Models, Molecular
  • Protein Conformation
  • Tyrosine / chemistry
  • Tyrosine / metabolism

Substances

  • Flavin-Adenine Dinucleotide
  • Tyrosine
  • FMN Reductase