Abstract
Four germacranolides, named calealactones A-C and calealactone B [corrected] were isolated from the leaves of Calea urticifolia (Compositae) in addition to three known germacranolides. Their structures were established on the basis of spectroscopic analysis including by 2D NMR spectroscopy. Calealactone C and 2,3-epoxyjuanisulamin displayed potent toxicity to U937 cells.
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Asteraceae / chemistry*
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Humans
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Leukemia
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plant Leaves / chemistry
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Sesquiterpenes, Germacrane / chemistry*
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Sesquiterpenes, Germacrane / isolation & purification
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Sesquiterpenes, Germacrane / pharmacology
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U937 Cells
Substances
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Antineoplastic Agents, Phytogenic
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Sesquiterpenes, Germacrane