Abstract
The lactoferrin-derived peptide hLF(1-11), but not its control peptide, was highly effective against five multidrug-resistant Acinetobacter baumannii strains in vitro (3 to 4 log reduction) and against four of these strains in an experimental infection in mice (2 to 3 log reduction). Therefore, this peptide is a promising candidate as a novel agent against infections with multidrug-resistant A. baumannii.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / drug therapy*
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Acinetobacter Infections / microbiology
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Acinetobacter baumannii / drug effects*
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Amino Acid Sequence
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Animals
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Colony-Forming Units Assay
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Dose-Response Relationship, Drug
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Drug Resistance, Multiple, Bacterial
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Lactoferrin
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Male
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Mice
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Molecular Sequence Data
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Peptide Fragments / therapeutic use*
Substances
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Peptide Fragments
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lactoferrin (1-11), human
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Lactoferrin