Adverse effect of verapamil in myasthenia gravis

Muscle Nerve. 1992 Mar;15(3):396-8. doi: 10.1002/mus.880150321.

Abstract

Verapamil, a class IV anti-arrhythmic drug that blocks voltage-dependent calcium channels in cardiac and smooth muscle, also has effects on presynaptic and postsynaptic voltage-dependent calcium channels at the neuromuscular junction. In a postoperative patient with pre-existent myasthenia gravis, oral verapamil caused a marked exacerbation in myasthenic weakness.

Publication types

  • Case Reports

MeSH terms

  • Contraindications
  • Coronary Artery Bypass
  • Coronary Disease / complications
  • Electromyography
  • Humans
  • Male
  • Middle Aged
  • Myasthenia Gravis / chemically induced*
  • Myasthenia Gravis / complications
  • Neuromuscular Junction / drug effects
  • Postoperative Complications / drug therapy
  • Tachycardia / drug therapy*
  • Verapamil / adverse effects*
  • Verapamil / therapeutic use

Substances

  • Verapamil